Product Data SheetProduct Name:CAS No.: Cat. No.:MWt:Formula:Purity :Carmofur61422-45-5HY-B0182257.26C11H16FN3O3>98%Solubility:DMSO 50 mg/mL; Water <1mg/mL; Ethanol 10 mg/mLMechanisms: Pathways:Cell Cycle/DNA Damage; Target:Nucleosideantimetabolite/analog gyBiological Activity:Carmofur is a derivative of fluorouracil, an antimetabolite used as an antineoplastic agent. Target: Nucleoside antimetabolite/analog Carmofur, which is used in the clinic to treat colorectal cancers, is a potent AC inhibitor and that thisproperty is essential to its anti-proliferative effects. Carmofur inhibited AC activity with a medianeffective concentration (IC50) of 29 ± 5 nM (mean ± standard error of the mean, s.e.m.; n = 4),whereas 5-FU had no such effect (IC50>1 mM). systemic administration of carmofur (10 or 30 mg-kg-1, intraperitoneal, i.p.) to mice produced a dose-dependent inhibition of AC activity in varioustissues, including lungs and brain cortex....ggReferences:[1]. Realini, N., et al., Discovery of highly potent acid ceramidase inhibitors with in vitro tumorchemosensitizing activity. Sci Rep, 2013. 3: p. 1035. Caution: Not fully tested. For research purposes onlyMedchemexpress LLCwww.medchemexpress.com18Wilkinson Way, Princeton, NJ 08540,USAEmail: info@medchemexpress.com Web: www.medchemexpress.com
