Inhibitors, Agonists, Screening Libraries
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Data Sheet
Product Name:Cat. No.:CAS No.:
Molecular Formula:Molecular Weight:Target:Pathway:Solubility:
MesnaHY-1367919767-45-4C2H5NaO3S21.18OthersOthers
10 mM in DMSO
BIOLOGICAL ACTIVITY:
2–mercaptoethane sulfonate (Mesna), is a synthetic small molecule, widely used as a systemic protective agent against chemotherapytoxicity, but is primarily used to reduce hemorrhagic cystitis induced by cyclophosphamide.
IC50 Value: 182 mM (decreased superoxide anion production stimulated with PMA (tetradecanoylphorbol acetate) in PMN in–vitro);70mM (inhibited H2O2 production) [3]Target:
in vitro: MESNA had no effect on the qualitative and quantitative characteristics of the indicated processes in both the types of thedoxorubicin sensitive cells. The combined use of doxorubicin and phosphamide or cyclophosphane the use of MESNA for lowering theurotoxic action of oxazophosphorines had no effect on the biological efficacy of doxorubicin [4].
in vivo: AMH–positive follicles were significantly decreased after cisplatin administration, which was significantly reversed when mesnawas co–administered with cisplatin. The end product of lipid peroxidation, malondialdehyde (MDA), was significantly increased, butthe anti–oxidative enzymatic activity of superoxide dismutase (SOD) and glutathione (GSH) were significantly decreased in cisplatingroups when compared with NS group. In contrast, after co–administration of cisplatin with mesna, MDA was significantly decreasedwhereas the activity of SOD and the concentration of GSH were increased. Moreover, mesna did not decrease the anti–tumor propertyof cisplatin in HePG2 cell lines [2]. After head trauma, tissue malondialdehyde levels increased; these levels were significantlydecreased by MESNA administration. Caspase–3 levels were increased after trauma, but no effect of MESNA was determined incaspase–3 activity [1].
Clinical trial: Effects of Mesna on Homocysteine in Kidney Failure . Phase2
References:
[1]. Yilmaz ER, Kertmen H, Gürer B, The protective effect of 2–mercaptoethane sulfonate (MESNA) against traumatic brain injury in rats. Acta Neurochir(Wien). 2013 Jan;155(1):141–9; discussion 149.
[2]. Li X, Yang S, Lv X, The mechanism of mesna in protection from cisplatin–induced ovarian damage in female rats. J Gynecol Oncol. 2013 Apr;24(2):177–85.[3]. Gressier B; Cabanis A; Lebegue S; Antioxidant Activity of Mesna: Interest During Pulmonary Inflammatory Diseases. Pharm.Weekbl. Sci.Ed., 1992, 14, No.5, Suppl. F, F48
[4]. Bogush TA, Smirnova GB, Chmutin EF, Effect of MESNA on intracellular accumulation of doxorubicin and its interaction with DNA. Antibiot Khimioter.1994 Sep–Oct;39(9–10):30–5.
Caution: Product has not been fully validated for medical applications. For research use only.
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